CLINICAL STUDY ON THE DEFINITION OF PERIMATRIX IN HUMAN EAR CHOLESTEATOMA

Objective To investigate the effects of middle ear,external auditory canal after the removal of epithelial matrix on the erosion of its behavior and to guide the way to determine cholesteatoma surgery and prognosis.Methods 60 cases of middle ear and 30 cases of external auditory canal were randomly divided into two groups with 45 cases in each.The first group received the removal of a cholesteatoma matrix,while the second group retained cholesteatoma matrix.Patients were observed after the dry ear rate,dry ear,cholesteatoma recurrence rate and microvessel count and cholesteatoma matrix surrounding tissue infiltration of inflammatory cells,and they were followed up for 3 months.Results Patients in both groups had the dry ear rates of 95.56% and 93.33% respectively(P0.05).The first group had the time of dry ear of(21.1 ± 4.8) d,while the second group(37.8 ± 3.7) d(P0.05).The first group had the cholesteatoma recurrence rate of being 4.44%,lower than 15.56% in the second group(P0.05).The skin microvascular count average after ear surgical epithelization was(5.1 ± 1.0) / mm2,while the average microvessel count of the cholesteatoma matrix was(22.1 ± 11.3) /mm2(P0.05).As the degree of inflammation around the matrix of cholesteatoma increased,the microvessel increased.Conclusion The counts of cholesteatoma matrix around the microvessel increased with increasing degree of inflammation.The formation of new blood vessels may be one of the main erosion behavior of cholesteatoma.In the middle ear and the external auditory canal after the removal of cholesteatoma epithelium,cholesteatoma matrix gradually lose the capacity of erosion.To remove or retain the cholesteatoma matrix of surgery has no effects on epithelization.