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1997•Chinese Journal of Clinical PharmacyRequires access

THE PHARMACOKINETICS AND BIOAVAILABILITY OF NIFEDIPINE SUSTAINED-RELEASE TABLETS IN YOUNG HEALTHY VOLUNTEERS

Zhao Zhi

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Abstract

The blood concentrations of two different nifedipine sustained-release tablets were determined by HPLC for studying on the pharmacokinetics and bioavailability in healthy volunteers. Disposed by 3P87 program, the conclusion showed: nifedipine was distributed and eliminated in two compartment model. Imported nifedipine was greater than native product in bioavailability and the elimination half time is longer than native product(P 0. 05).

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What this paper is about

The blood concentrations of two different nifedipine sustained-release tablets were determined by HPLC for studying on the pharmacokinetics and bioavailability in healthy volunteers. Disposed by 3P87 program, the conclusion showed: nifedipine was distributed and eliminated in two compartment model. Imported nifedipine was greater than native product in bioavailability and the elimination half time is longer than native product(P 0. 05).

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Available abstract

The blood concentrations of two different nifedipine sustained-release tablets were determined by HPLC for studying on the pharmacokinetics and bioavailability in healthy volunteers. Disposed by 3P87 program, the conclusion showed: nifedipine was distributed and eliminated in two compartment model. Imported nifedipine was greater than native product in bioavailability and the elimination half time is longer than native product(P 0. 05).

Key concepts: Bioavailability, Nifedipine, Pharmacokinetics, Pharmacology, Bioequivalence, Chemistry, Medicine, Internal medicine

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THE PHARMACOKINETICS AND BIOAVAILABILITY OF NIFEDIPINE SUSTAINED-RELEASE TABLETS IN YOUNG HEALTHY VOLUNTEERS — Research Paper | ScholarLens