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The Study on Relationship Between Polymorphism of Angiotensinogen Gene and Essential Hypertension

Zhiqiong Hu

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Abstract

Objective To explore the relationship between the M235T polymorpyism of AGT and essential hypertension in Chongqing urban sampling population. Methods Population-based case-control study was conducted using PCR-RFLP techniques to analyze polymorphism of M235T. Results 78 subjects with hypertension and 84 with normotension were tested. The frequency of TT genotype in essential hypertension cases was higher than that in controls (32.05%: 21.34%). The odds ratio (OR) was 3.86. So did the T allele (73%: 59%). Comparing with MM genotype, the more of allele T, the higher risk of essential hypertension(P 0.001). Conclusions M235T allele gene of AGT maybe the susceptible genotype of essential hypertension in Chongqing population.

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What this paper is about

Objective To explore the relationship between the M235T polymorpyism of AGT and essential hypertension in Chongqing urban sampling population. Methods Population-based case-control study was conducted using PCR-RFLP techniques to analyze polymorphism of M235T. Results 78 subjects with hypertension and 84 with normotension were tested. The frequency of TT genotype in essential hypertension cases was higher than that in controls (32.05%: 21.34%). The odds ratio (OR) was 3.86. So did the T allele (73%: 59%). Comparing with MM genotype, the more of allele T, the higher risk of essential hypertension(P 0.001). Conclusions M235T allele gene of AGT maybe the susceptible genotype of essential hypertension in Chongqing population.

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Available abstract

Objective To explore the relationship between the M235T polymorpyism of AGT and essential hypertension in Chongqing urban sampling population. Methods Population-based case-control study was conducted using PCR-RFLP techniques to analyze polymorphism of M235T. Results 78 subjects with hypertension and 84 with normotension were tested. The frequency of TT genotype in essential hypertension cases was higher than that in controls (32.05%: 21.34%). The odds ratio (OR) was 3.86. So did the T allele (73%: 59%). Comparing with MM genotype, the more of allele T, the higher risk of essential hypertension(P 0.001). Conclusions M235T allele gene of AGT maybe the susceptible genotype of essential hypertension in Chongqing population.

Key concepts: Essential hypertension, Genotype, Allele, Odds ratio, Allele frequency, Polymorphism (computer science), Internal medicine, Genetics

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