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2007•Shenzhen Journal of Integrated Traditional Chinese and Western MedicineRequires access

Prognosis and the Expression of Survivin Protein and Proliferating Cell Nuclear Antigen (PCNA) in Hepatocellular Carcinoma

Chengyou Wang

Open publisher page 1 citations

Abstract

Objective To study the expression of survivin protein and proliferating cell nuclear antigen (PCNA) in hepatocellular carcinoma (HCC) and the prognosis of HCC. Methods The expression of survivin protein and proliferating cell nuclear antigen (PCNA) in 46 cases of HCC were determined by immunohistochemistry method. Results The survivin protein expressed in 31 of 46 cases of HCC (67.4%). The expression of PCNA was significantly higher in the HCC with positive survivin expression than in the HCC with negative survivin expression. The patients with positive survivin expression had a worse survival rate of 2-year than the patients with negative survivin expression. Conclusion The expression of survivin may play an important role in the proliferation of HCC cells and closely associate with the prognosis of HCC.

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What this paper is about

Objective To study the expression of survivin protein and proliferating cell nuclear antigen (PCNA) in hepatocellular carcinoma (HCC) and the prognosis of HCC. Methods The expression of survivin protein and proliferating cell nuclear antigen (PCNA) in 46 cases of HCC were determined by immunohistochemistry method. Results The survivin protein expressed in 31 of 46 cases of HCC (67.4%). The expression of PCNA was significantly higher in the HCC with positive survivin expression than in the HCC with negative survivin expression. The patients with positive survivin expression had a worse survival rate of 2-year than the patients with negative survivin expression. Conclusion The expression of survivin may play an important role in the proliferation of HCC cells and closely associate with the prognosis of HCC.

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Available abstract

Objective To study the expression of survivin protein and proliferating cell nuclear antigen (PCNA) in hepatocellular carcinoma (HCC) and the prognosis of HCC. Methods The expression of survivin protein and proliferating cell nuclear antigen (PCNA) in 46 cases of HCC were determined by immunohistochemistry method. Results The survivin protein expressed in 31 of 46 cases of HCC (67.4%). The expression of PCNA was significantly higher in the HCC with positive survivin expression than in the HCC with negative survivin expression. The patients with positive survivin expression had a worse survival rate of 2-year than the patients with negative survivin expression. Conclusion The expression of survivin may play an important role in the proliferation of HCC cells and closely associate with the prognosis of HCC.

Key concepts: Survivin, Proliferating cell nuclear antigen, Immunohistochemistry, Cancer research, Hepatocellular carcinoma, Medicine, Antigen, Pathology

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Prognosis and the Expression of Survivin Protein and Proliferating Cell Nuclear Antigen (PCNA) in Hepatocellular Carcinoma — Research Paper | ScholarLens