Liver fat contents in type 2 diabetic patients with nonalcoholic fatty liver disease under metformin treatment

Objective To investigate the change of liver fat contents in type 2 diabetic patients with non-alcoholic fatty liver disease(NAFLD) under metformin treatment.Methods Fifty patients with type 2 diabetes mellitus(T2DM) and NAFLD were assigned to receive metformin treatment(groupA,n=25) or non-metformin treatment(group B,n=25).The intrahepatic fat contents were examined by MRS;the mass of fat peak/the mass of fat peak + the mass of water peak 5.5% was diagnosed as NAFLD.Results Twenty four cases in each group were completed with treatment and followed up.There were no significant differences in liver fat accumulation between two groups(P0.05);however,after treatment the TC,BMI,FPG,HbA1c and TG levels in group A were significantly lower than those in group B.Conclusion Metformin can improve glycometabolism in T2DM patients with NAFLD.