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2008•Journal of Practical Diagnosis and TherapyRequires access

Evaluation of excretory-secretory antigen and crude antigen of C.sinensis adult larvae for the serodiagnosis of clonorchiasis by ELISA

Wu Xiuping

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Abstract

Objective To analyze the sensitivity and specificity of excretory-secretory antigen and crude antigen as diagnostic antigens for the serodiagnosis of clonorchiasis by ELISA.Methods Excretory-secretory antigen and crude antigen of C.Sinensis adult larvae was used to detect 107 positive sera and 50 negative sera of clonorchiasis patients by ELISA, in which,all of the sera were confirmed by egg examination of dejecta.The sensitivity and specificity of two antigens were compared and evaluated.Results The sensitivities of excretory-secretory antigen and crude antigen were 87.85% and 58.88%,respectively(P0.05).The specifities of two antigens were 100% and 98%,respectively(P0.05).Coincidence from two antigens was 91.72% and 71.34%,respectively(P0.05).Conclusion Either sensitivity or specificity of excretory-secretory antigen is better than that of crude antigen for the serodiagnosis of clonorchisis by ELISA.

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Objective To analyze the sensitivity and specificity of excretory-secretory antigen and crude antigen as diagnostic antigens for the serodiagnosis of clonorchiasis by ELISA.Methods Excretory-secretory antigen and crude antigen of C.Sinensis adult larvae was used to detect 107 positive sera and 50 negative sera of clonorchiasis patients by ELISA, in which,all of the sera were confirmed by egg examination of dejecta.The sensitivity and specificity of two antigens were compared and evaluated.Results The sensitivities of excretory-secretory antigen and crude antigen were 87.85% and 58.88%,respectively(P0.05).The specifities of two antigens were 100% and 98%,respectively(P0.05).Coincidence from two antigens was 91.72% and 71.34%,respectively(P0.05).Conclusion Either sensitivity or specificity of excretory-secretory antigen is better than that of crude antigen for the serodiagnosis of clonorchisis by ELISA.

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Available abstract

Objective To analyze the sensitivity and specificity of excretory-secretory antigen and crude antigen as diagnostic antigens for the serodiagnosis of clonorchiasis by ELISA.Methods Excretory-secretory antigen and crude antigen of C.Sinensis adult larvae was used to detect 107 positive sera and 50 negative sera of clonorchiasis patients by ELISA, in which,all of the sera were confirmed by egg examination of dejecta.The sensitivity and specificity of two antigens were compared and evaluated.Results The sensitivities of excretory-secretory antigen and crude antigen were 87.85% and 58.88%,respectively(P0.05).The specifities of two antigens were 100% and 98%,respectively(P0.05).Coincidence from two antigens was 91.72% and 71.34%,respectively(P0.05).Conclusion Either sensitivity or specificity of excretory-secretory antigen is better than that of crude antigen for the serodiagnosis of clonorchisis by ELISA.

Key concepts: Antigen, Clonorchiasis, Excretory system, Clonorchis sinensis, Medicine, Immunology, Biology, Helminths

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Evaluation of excretory-secretory antigen and crude antigen of C.sinensis adult larvae for the serodiagnosis of clonorchiasis by ELISA — Research Paper | ScholarLens