Effect of Qishenhuanwu Capsule on the cortex neurosynapses in rats with cerebral ischemia

Objective To observe the effect of Qishenhuanwu Capsule on neurosynapses of cerebral cortex in rats with cerebral ischemia.Methods The rat models of cerebral ischemia were made by middle cerebral artery occlusion with the intraluminal filament obstruction,the changes of the parietal lobe synapses in rats of sham-operation group,placebo control group and Qishenhuanwu Capsule therapy group were observed with electron transmission microscopy.Results The placebo control group showed decreased number of synaptic terminals,obscure synaptic structures,enlarged mitochondria and reduced quantity of synaptic vesicles,even broken and fused,all of which had significant changes when compared with that of the sham-operation group.By contrast,Qishenhuanwu Capsule therapy group demonstrated the synaptic structure rather clearer and more complete,which improved markedly in comparison with that in the other groups.Conclusion In cerebral ischemia cortical neurosynaptic structures in parietal lobes were damaged,Qisbenhuanwu Capsule could protect the integrity of neurosynaptic structure around the focal ischemia lesion,it provide ultrastructural foundation for brain functional reconstruction.