2010•Shengming kexueRequires access

Reviews on pyruvate decarboxylase and its application

Haoming Li

Abstract

Pyruvate decarboxylase,EC4.1.1.1,an intracellular enzyme,is a thiamine pyrophosphate-dependent non-oxidative enzyme.The holoenzyme,composed of coenzyme ThPP,Mg2+ and protein,catalyzes the non-oxidative decarboxylation of pyruvate to acetaldehyde using Mg2+ and thiamine pyrophoshate(ThPP) as cofactors.Pyruvate decarboxylase(PDC) is the key enzyme for all homo-fermentative ethanol pathways,and widely distributed among plants,yeasts,fungi,and bacteria.Pyruvate decarboxylases from different sources are not quite similar in structure,molecular weight,characterization and so on.This paper reviews the biological properties of pyruvate decarboxylase and its application.

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Available abstract

Key concepts: Pyruvate decarboxylase, Pyruvate decarboxylation, Dihydrolipoyl transacetylase, Biochemistry, Carboxy-lyases, Decarboxylation, Thiamine pyrophosphate, Pyruvate dehydrogenase phosphatase