Application of Regional Cerebral Blood Flow Tomography in Constraint-Induced Movement Therapy Appraisal among Hemiplegic Stroke Patients

Objective To observe the change of regional cerebral blood flow(rCBF) before and after constraint-induced movement therapy(CIMT) treatment and to probe the clinical values of cerebral blood flow tomography in constraint-induced movement therapy appraisal among hemiplegic stroke patients.Methods Nine qualified hemiplegic stroke patients were enrolled and underwent CIMT therapy for a period of six weeks.The ratio of radioactivity countof the ischemia focus area(L) and radioactivity count of the normal side(N)was applied for semi-quantitative analysis of rCBF,which was compared before and six weeks after treatment.At the same time,walking ability was assessed through maximum walking speed(MWS) before and six weeks after treatment.Results L/N ratios were different before treatment(0.54±0.25)(95% confidence interval(0.45,0.68)) and after treatment(0.98±0.52)(95% confidence interval(0.87,1.21)) with statistical significance(P0.01).MWS raised from(17.44±10.85)s/10 m before treatment to(10.57±6.91)s/10 m after treatment(P0.01).Improvment of ischemia regional cerebral blood flow was consistent with that of walking ability.Conclusion Cerebral blood flow changes displayed by regional cerebral blood flow tomography may effectively evaluate therapeutic effects of CIMT.