Effect of Sijunzi Decoction on Intestinal Function after Relieving Obstruction of Rabbit with Recoverability Intestinal Obstruction Model

Objective To observe the effect of Sijunzi decoction on enteric movement and absorptive function after relieving intestinal obstruction in utilizing recoverability intestinal obstruction model.Methods The laboratory rabbits were randomly divided into 3 groups including control group(Count),sham operated group(Sham) and Model group(6 in each).Rabbits in model group were made into steady controllable model of mechanical complete intestinal obstruction and naturally recovered after 48 hours.Rabbits underwent intragastric administration with physiological saline and Sijunzi decoction respectively and divided into spontaneous recovery 48 hours group(S48 h),spontaneous recovery 96 hours group(S96 h),treatment of Sijunzi decoction 48 hours group(T48 h) and T96 h group(6 in each).Rabbits were put to death after relieving intestinal obstruction.Insta-Char(20 ml/kg) and 10% D-Xylose solutions were injected respectively on 30 minute and 2 hours before death.Carbo Medicinalis propulsion rates of each group,D-xylose in small intestinal absorption and the pathological changes of small intestine were observed and been compared with those in control group and sham operated group.Results Repair of small intestinal epithelial cells by Chinese Medicines was significantly better than that in natural recovery group of the same period.After relieving intestinal obstruction the level of Carbo Medicinalis propulsion rates in S48 h,T48 h,S96 h groups were significantly lower than those in control group(P0.05);at the same period Carbo Medicinalis propulsion rate and D-xylose in small intestinal absorption in Chinese Medicine treatment group were significantly better than those in control group(P0.05).Conclusion Sijunzi decoction can efficiently restore the intestinal movement function and intestinal absorption function after relieving obstruction.