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2007•Chinese Journal of MisdiagnosticsRequires access

Hyperkeratosis of Nipple and Areola Complicated with Human Papillomavirus Infection:A Case Report and Literature Review

Yizhi Zhang

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Abstract

Objective:To explore the clinic and pathological characteristics of Hyperkeratosis of nipple and areola(HNA)and assess the association of HNA and Human papillomavirus(HPV).Methods:The clinic data of one case of HNA complicated with HPV infection was analyzed and the relevant literatures were reviewed.Results:HNA was a rare and benign condition.Verrucous thickening and pigmentation of the nipple and/or areola were the main features of the condition.The histopathological changes showed hyperkeratosis,acanthosis,papillomatosis,and lymphocytic infiltrate in the dermis.The patient was complicated with HPV infection.The immunohistochemical examination showed the total HPV(+),HPV-6 and HPV-11(-).Conclusion:The diagnosis of HNA is mainly dependented on the clinic and pathologic way.There is no specific treatment for this disease now.

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What this paper is about

Objective:To explore the clinic and pathological characteristics of Hyperkeratosis of nipple and areola(HNA)and assess the association of HNA and Human papillomavirus(HPV).Methods:The clinic data of one case of HNA complicated with HPV infection was analyzed and the relevant literatures were reviewed.Results:HNA was a rare and benign condition.Verrucous thickening and pigmentation of the nipple and/or areola were the main features of the condition.The histopathological changes showed hyperkeratosis,acanthosis,papillomatosis,and lymphocytic infiltrate in the dermis.The patient was complicated with HPV infection.The immunohistochemical examination showed the total HPV(+),HPV-6 and HPV-11(-).Conclusion:The diagnosis of HNA is mainly dependented on the clinic and pathologic way.There is no specific treatment for this disease now.

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Available abstract

Objective:To explore the clinic and pathological characteristics of Hyperkeratosis of nipple and areola(HNA)and assess the association of HNA and Human papillomavirus(HPV).Methods:The clinic data of one case of HNA complicated with HPV infection was analyzed and the relevant literatures were reviewed.Results:HNA was a rare and benign condition.Verrucous thickening and pigmentation of the nipple and/or areola were the main features of the condition.The histopathological changes showed hyperkeratosis,acanthosis,papillomatosis,and lymphocytic infiltrate in the dermis.The patient was complicated with HPV infection.The immunohistochemical examination showed the total HPV(+),HPV-6 and HPV-11(-).Conclusion:The diagnosis of HNA is mainly dependented on the clinic and pathologic way.There is no specific treatment for this disease now.

Key concepts: Hyperkeratosis, Acanthosis, Papillomatosis, Medicine, Areola, Dermatology, Pathological, HPV infection

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