Expression of PTEN gene in human laryngeal carcinoma and its clinical significance

Objective: To detect the mRNA expression of PTEN gene in laryngeal carcinoma, and to explore its clinical significance. Methods: The mRNA expression of PTEN in 40 tumor samples and 9 normal laryngeal samples were examined with RT-PCR. Results: The mRNA expression of PTEN in the normal laryngeal tissue was higher than that in the laryngeal cancer with lymph node metastasis (P0.05). The difference between high and low differentiation of laryngeal carcinoma was statistically significant (P0.05). Conclusion: The decreasing of mRNA expression PTEN may be related with the lymph node metastasis and low differentiation of laryngeal squamous cell carcinoma, which suggested that the decreasing of PTEN gene expression may take important effects in the progression of laryngeal carcinoma.