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2002•Academic Journal of Second Military Medical UniversityRequires access

Expression of epidermal growth factor receptor in Chinese brain astrocytoma

Yong Chen

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Abstract

Objective: To investigate the expression of epidermal growth factor receptor(EGFR) in astrocytoma specimen in Chinese and its relationship with tumor grade. Methods: The expression of EGFR in human astrocytoma specimen, several cultured human and rat glioma cell lines were examined by immunohistochemistry staining.Results: The average expression of EGFR in astrocytoma tissues(70.3%,26/37) was significantly higher than that in adjacent tissues(32.4%,12/37, P 0.01).The expression of EGFR was positively correlated with tumor grade,EGFR expression in grade Ⅲ Ⅳ(21/25) was significantly higher than that in gradeⅠ Ⅱ (5/12, P 0.01).Heterogenous glioma cell lines presented different levels of EGFR expression.Conclusion: EGFR is overexpressed in Chinese astrocytoma.EGFR can be regarded as an indicator of malignant potential and a molecular marker for gliomas.

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Objective: To investigate the expression of epidermal growth factor receptor(EGFR) in astrocytoma specimen in Chinese and its relationship with tumor grade. Methods: The expression of EGFR in human astrocytoma specimen, several cultured human and rat glioma cell lines were examined by immunohistochemistry staining.Results: The average expression of EGFR in astrocytoma tissues(70.3%,26/37) was significantly higher than that in adjacent tissues(32.4%,12/37, P 0.01).The expression of EGFR was positively correlated with tumor grade,EGFR expression in grade Ⅲ Ⅳ(21/25) was significantly higher than that in gradeⅠ Ⅱ (5/12, P 0.01).Heterogenous glioma cell lines presented different levels of EGFR expression.Conclusion: EGFR is overexpressed in Chinese astrocytoma.EGFR can be regarded as an indicator of malignant potential and a molecular marker for gliomas.

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Available abstract

Objective: To investigate the expression of epidermal growth factor receptor(EGFR) in astrocytoma specimen in Chinese and its relationship with tumor grade. Methods: The expression of EGFR in human astrocytoma specimen, several cultured human and rat glioma cell lines were examined by immunohistochemistry staining.Results: The average expression of EGFR in astrocytoma tissues(70.3%,26/37) was significantly higher than that in adjacent tissues(32.4%,12/37, P 0.01).The expression of EGFR was positively correlated with tumor grade,EGFR expression in grade Ⅲ Ⅳ(21/25) was significantly higher than that in gradeⅠ Ⅱ (5/12, P 0.01).Heterogenous glioma cell lines presented different levels of EGFR expression.Conclusion: EGFR is overexpressed in Chinese astrocytoma.EGFR can be regarded as an indicator of malignant potential and a molecular marker for gliomas.

Key concepts: Astrocytoma, Epidermal growth factor receptor, Immunohistochemistry, Glioma, Pathology, Cancer research, Biology, Epidermal growth factor

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