Advancement of antihistamine drugs application

Antihistamine have already widely been used in clinic to cure allergic disease. Because first generation antihistamines have been shown to produce sedation side effect, their clinical use is influenced. Second generation antihistamines produced late in the 80's of 20 th have many characteristics, such as high selectivity of H 1 receptor, non sedation, and histamine isolation and so on. Thus second generation antihistamines are called non sedating antihistamines (NSA). However, Some of them also have adverse reaction, especially cardiotoxicity, which is related to antihistamines drugs interaction, pharmacokinetics and drug molecular structure. In 1997, fexofenadine, a new antihistamic drug, made an appearance. It is fast action, high effection, relative safety and low toxicant antihistamine. The exploitation of fexofenadine establishs new way to look for antihistamic drugs which have neigher sedating effects on the central nervous system nor cardiotoxicity.