Analysis of relative risk factors for diabetic nephropathy

Objective:To study relative risk factors for diabetic nephropathy(DN).Methods:A total of 238 patients diagnosed as type 2 diabetes mellitus(DM) were enrolled in the study.According to urine microalbuminuria to urine creatinine ratio(UACR),patients were divided into pure DM group(group DM1,n=90),early diabetic nephropathy group(group DM2,n=73) and clinical diabetic nephropathy group(group DM3,n=75).Clinic data of all patients were collected;Fasting blood glucose(FBG),2h postprandial blood glucose(2hPB),blood lipids,uric acid(UA),fibrinogen(Fg) and glycosylated haemoglobin(HbA1c) were measured in all patients,and their correlations with DN were analyzed.Results:Compared with group DM1,the course of disease in DM [(7.25±6.29) years vs.(10.25±7.67) years vs.(13.53±7.82) years],levels of FBG [(8.46±2.52) mmol/L vs.(9.52±3.38) mmol/L vs.(10.82±3.30) mmol/L],2hPB [(18.40±5.64) mmol/L vs.(20.27±5.94) mmol/L vs.(22.59±6.14) mmol/L],HbA1c [(7.96±1.65)% vs.(8.60±1.76)% vs.(9.55±2.09)%],triglyceride,Fg [(3.49±0.93) g/L vs.(3.88±1.21) g/L vs.(4.99±2.10) g/L]and UA [(295.42±52.34) μmol/L vs.(324.18±96.29) μmol/L vs.(351.23±56.88) μmol/L]significantly increased in group DM2 and group DM3 in order(P0.01~0.001).Logistic gradual regression analysis indicated that course of DM,HbA1c,TG,Fg and UA were risk factors for DN(OR=1.008~1.910,P0.01~0.001).Conclusion:The course of DM,blood glucose,blood lipid,uric acid and fibrinogen are risk factors for diabetic nephropathy;increased UACR reflects progress of patients′ condition in DM patients,its detection is used for diabetic prognosis and treatment.