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Development in Study of SDF-1/CXCR4 and Prostate Cancer

Jia Hao Wang

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Abstract

Metastasis is a major cause of morbidity in prostate cancer(PCa).Several studies have shown that the chemokine receptor CXCR4 and its ligand,SDF-1(stromal cell-derived factor-1),regulate tumor cell metastasis to specific organs.Recently,it was demonstrated that SDF-1 enhances PCa cell adhesion,migration,and invasion,implicating CXCR4 in PCa metastasis.As the specific inhibitors of chemokine receptor CXCR4:AMD3100,T22,T140 and human scFv have been confirmed to inhibit the metastasis of tumor cells in vitro,and have a wide clinical application in the prevention and treatment of PCa metastasis.

About this research paper

What this paper is about

Metastasis is a major cause of morbidity in prostate cancer(PCa).Several studies have shown that the chemokine receptor CXCR4 and its ligand,SDF-1(stromal cell-derived factor-1),regulate tumor cell metastasis to specific organs.Recently,it was demonstrated that SDF-1 enhances PCa cell adhesion,migration,and invasion,implicating CXCR4 in PCa metastasis.As the specific inhibitors of chemokine receptor CXCR4:AMD3100,T22,T140 and human scFv have been confirmed to inhibit the metastasis of tumor cells in vitro,and have a wide clinical application in the prevention and treatment of PCa metastasis.

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Available abstract

Metastasis is a major cause of morbidity in prostate cancer(PCa).Several studies have shown that the chemokine receptor CXCR4 and its ligand,SDF-1(stromal cell-derived factor-1),regulate tumor cell metastasis to specific organs.Recently,it was demonstrated that SDF-1 enhances PCa cell adhesion,migration,and invasion,implicating CXCR4 in PCa metastasis.As the specific inhibitors of chemokine receptor CXCR4:AMD3100,T22,T140 and human scFv have been confirmed to inhibit the metastasis of tumor cells in vitro,and have a wide clinical application in the prevention and treatment of PCa metastasis.

Key concepts: Medicine, Metastasis, CXCR4, Stromal cell, Prostate cancer, Chemokine receptor, Cancer research, Chemokine

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