The curative effect of different dose of calcitriol on uremic hemodialysis patients with secondary hyperparathyroidism

Objective To compare the therapeutical effect of routine dose of calcitriol and large dose impulsion therapy on hemodialy patients with secondary hyperparathyroidism (SHPT).Methods 48 Uremic hemodialysis patients were divided into group A(routine group,n=22) and group B(contrast group,n=21).In group A,22 patients were administrated with calcitriol for 6 months at the dosage of 0.25～0.5*!μg·d -1 ,adding calcium agents simultaneously;The patients in Group B were not given calcitriol for economic reason.In group C,21 patients were given calcitriol twice a week at the dosage of 2*!μg/time after hemodialysis for 3 months.Results Comparing group B,serum PTH、AKP in group A had no significant different,but serum hypocalcium and hyperphasphate were partly corrected,symptoms of bone pain,muscular convulsion and skin pruriter were improved.Comparing to group A,serum hypocalcium and hyperphasphate in group C were corrected,serum PTH、AKP were significantly decreased(t=2.031,P 0.05 ;t=3.317,P 0.001 ),and no hypercalcium occurred.Conclusions Routine dose of calcitriol can not control uremic-SHPT,while impulsion therapy with lower dose oral calcitriol is effective and safe.