Research Progress of Myeloid-derived Suppressor Cells Involved in Tumor Immune Escape

Tumors escape immune recognition by several mechanisms,and myeloid derived suppressor cells( MDSCs) play a major role in tumor mediated immune evasion. MDSCs are a group of heterogeneous cell derived from myeloid progenitor cells and immature myeloid cells in bone marrow granulocytes. MDSCs promote tumors progression through inhibiting both innate and acquired immunity. Here is to make a review of the progress of MDSCs and its surface markers,the recruitment and activation,the MDSC-mediated immune escape mechanisms and antitumor treatment targeting at MDSC.