2010•The Chinese Journal of DermatovenereologyRequires access
Expressions of CD25 in CD4+ T cells and CD28 in CD8+ T cells in HIV/AIDS patients.
Qian Yu, Wang Ye-kai, Shiquan Zhou
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Abstract
Objective To study the expressions of CD25 in CD4+ T cells and CD28 in CD8+ T cells in the peripheral blood of HIV/AIDS. Methods CD25 in CD4+ T cells and CD28 in CD8+ T cells in the peripheral blood of 35 HIV/AIDS and 41 normal control were detected by flow cytometr. Results It shows that in patients with HIV/AIDS and the normal subjects,the expression percent of CD25 in CD4+T cells(27.51±4.23)%,(44.41±9.17)%、CD4+25+T cells(2.00±1.42)%,(16.62±4.60)%、CD4+25-T cells(5.16±3.37)%,(21.03±6.19)%、CD28 in CD8+T cells(25.12±6.33)%,(44.24±8.61)%, CD8+28-T cells(36.85±8.98)%,(13.33±4.58)%had significantly different (P0.01);CD8+28+T cells(12.31±4.14)%,(10.51±3.71)%had no significantly different (P0.05). Conclusions The low expression of CD25 in CD4+ T cells and CD28 in CD8+ T cells in HIV infection patients was closely associated with Immunodeficiency by HIV infection, the increase of CD8+28-T cells help to promote HIV/AIDS patients with inflammatory response and immune activation.