Expression changes and significance of SV2A in the hippocampus of rats with amygdala-kindling epilepsy models

Objective To establish the amygdala-kindling epilepsy rats models,and measure the expression of SV2A to explore the pathogenesis of epilepsy.Methods To establish model of chronic epilepsy by stimulating the amygdala as the epilepsy group,and to perfuse antiepileptic drug of levetiracetam into stomach as the treatment group.The dynamic changes of SV2A were examined by Real-time PCR and immunohistochemistry in the hippocamp tissue.Results Compared with the sham control group,epilepsy group showed decreased the expression after one week,and SV2A in epilepsy eight weeks was higher than control group(P0.05).However,there was significant difference between group after two weeks,four weeks and eight weeks before and after treatment(P0.05).Conclusion The expression of SV2A was closely related to epileptic seizures.