Clinical Features of IgM Nephropathy:Report of 10 Cases

Objective To observe the clinical features of IgM nephropathy.Methods Retrospective analysis of the clinical manifestations,pathologic features,characteristic of urinary podocyte excretion,treatment method and therapeutic reaction were carried out in 10 patients with IgM nephrology.Results Of the 10 patients(6 males and 4 females),9 were with nephrotic syndrome and one was with glomerulonephritis.Microscopic hematuria was noted in 3 cases and no gross hematuria was noted at all.Pathologic changes were mesangial proliferation of mild to moderate degrees with granular IgM deposit seen in the mesangial areas in all cases.No podocyte excretion was found in 9 out of the 10 cases and minimal excretion was noted in 1 case(2/20HP).Satisfiable treating response was achieved with complete remission occurred in 9 cases,effectiveness in 1 case,and relapse in 3 cases.Treatment with steroids and Lefloumint(alone or combined) were all effective.Conclusion Clinical features of IgM nephropathy primarily represent nephrotic syndrome.Pathologic changes are mild to moderate degrees of mesangial proliferation.Granular IgM deposit is seen in mesangial areas in all cases.No podocyte excretion is found in the urine.Satisfiable responses to steroids and immunosuppressants are noted.