Clinical and pathological analysis of 40 cases of cutaneous squamous cell carcinoma

Objective To study the clinical and pathological features,malignancy and prognosis of cutaneous squamous cell carcinoma(SCC).Methods 42 patients with SCC were collected,and their clinical features were analyzed with pathological aspects observed by immunohistochemical SP techniques.Results Clinically,SCC of most commonly consists of a shallow ulcer surrounded by a wide,elevated,indurated border.Often the ulcer is covered by a crust that conceals a red,granular base.On histologic examination,one finds the tumor to consist of irregular masses of epidermal cells that proliferate downward into the dermis.The Broders′ classification depends on the differentiation of squamous cells.The expression levels of p16 was lower than controls(P0.05),whereas pRb was higher than controls(P0.05).Conclusion SCC is a common skin malignant tumor with it′s typical clinical and pathological features.The diagnosis,malignancy and prognosis of SCC can be confirmed by immunohistochemical staining.