Characteristics of Brain Edema after Intracerebral Hemorrhage in Rats

Aim:To investegate the characteristics of brain edema after intracerebral hemorrhage in rats and provide theoretic basis for therapy or illness evaluation in intracerebral hemorrhage patients.Methods:The model of caudate nucleus hemorrhage in rats was established.The changes of brain water content in different regions and time as 1,2,3,5,7 days after intracerebral hemorrhage were measured by the wet and dry weight methods,the result was compared with the normal rats.Results:As shown in the isilateral basal ganglia and isilateral cortex,the marked increase of brain water content was within 24 h after intracerebral hemorrhage,the peak at 3 days,and the brain edema did not disappear after 7 days,while in the contralateral basal ganglia and contralateral cortex there was no significant increase in brain water content.Conclusion:The formation of brain edema after intracerebral hemorrhage in rats was within 24 h ,its peak at 3 days.The brain edema in the intracerebral hemorrhage patients should be treated as soon as possible.