P53 protein expression in epithelial ovarian carcinoma

Objective To investigate the prognostic value of P53 expression for the epithelial ovarian carcinoma and to establish an effective index to predict the progression and prognosis.Methods P53 protein expression was examined by immunohistochemical method in 72 patients with epithelial ovarian carcinoma and clinical staging,histologic types,tissue differentiation was analyzed.Results The P53 protein was less expressed in G1 and G2 groups than in G3 group.Moreover,P53 protein expression varied among different clinical stages.P53 expression in stagesⅠ and Ⅱwere less than that of stages Ⅲ and Ⅳ.There was no significant difference between P53 expression and histological types.The P53 expression was associated with the 5-year survival-free rate in patients with P53 negative and P53 positive were 60.71% and 27.27%,respectively,the difference was significant((P)0.05).Conclusion P53 protein expression related with the histological grade and clinical stages,but not with the histological type.P53 expression could be as a factor both in predicting prognosis of patients and anti-cancer drug resistance in epithelia ovarian cancer.