Effects of different TCI concentrations of sufentanil on sedation and hypnosis effects of TCI propofol

Objective To estimate the effects of TCI different concentrations of sufentanil on sedation and hypnosis effects of TCI propofol. Methods Sixty patients, ASAⅠ～Ⅱ, aged 25～60 years old, were enrolled and divided randomly into four groups. Group A received TCI propofol alone, group B, C and D received TCI sufentanil before TCI propofol and effect site target concentration(Ct) of sufentanil were 0.1, 0.2 and 0.3 ng/ml respectively. Target concentration (Ct) of propofol was increased step-by-step from 1 to 3 μg/ml in five steps. Only after the Ct of propofol was maintained at each step for 1 min, OAA/S and bispectral index (BIS) were recorded. OAA/S and BIS were also recorded after 1 min of Ct of sufentanil was reached. Results TCI sufentanil alone did not affect patients’ BIS and OAA/S. BIS and OAA/S decreased with increase of propofol Ct in all groups. At the same Ct of propofol, there was no significant difference in BIS among all groups. OAA/S in group D was significantly lower than that in group A when the Ct of propofol was 1.0～2.0 μg/ml (P 0.05). Conclusions During period of induction, sufentanil of effect concentrations at 0.1 and 0.2 ng/ml does not enhance sedation and hypnosis effects of propofol. Sufentanil in 0.3ng/ml may enhance sedation and hypnosis effects of propofol.