Significance of brain natriuretic peptide and homocysteine in patients with acute coronary syndrome

Objective:To explore the variation and significance of brain natriuretic peptide(BNP)and homocysteine(Hcy) in patients with acute coronary syndrome(ACS).Methods:The study population consisted of 82 ACS patients,30 patients with stable angina pectoris(SAP) and 34 healthy controls with normal coronary artery angiography(CAG).Plasma BNP was measured by fluoroimmunoassay at 24 h in patients with ACS after the onset of ischemic symptoms.Hcy was measured using high performance liquid chromatography(HPLC)with fluorescence detection,ACS patients were divided into unstable angina pectoris(UAP)group and acute myocardial infarction(AMI)group.Results:The plasma BNP level in ACS group was significantly higher than that in SAP group and control group(P0.01 all).The level of BNP in AMI group was more than that of UAP group(P0.05).The plasma Hcy level in ACS group was higher than that in SAP group and control group(P0.01 all).Conclusion:Plasma BNP and Hcy levels increase significantly in patients with ACS.It suggests that BNP and Hcy play an important role in the pathophysiology of ACS.