THE EFFICACY OF ARTIFICIAL LIVER SUPPORT SYSTEM FOR HEPATITIS E

Objective To investigate the clinical effect of artificial liver support system(ALSS) in treating hepatitis E.Methods Thirty-nine patients with hepatitis E were treated by using plasma exchange(PE),plasma perfusion(PP) and hemoperfusion(HP) plus hemodialysis(HD).The efficacy was assessed and the changes of serum TBIL,ALT,AST,ALB,CHOL,TBA,BUN,Cr and PTA were measured before and after therapy. Results Clinical symptoms and liver function of the patients improved after treatment.Serum albumin and PTA increased,and serum bilirubin and TBA decreased(t=2.61-10.11,P0.01),renal function was not much affected(P0.05).This modality of therapy did not markedly influence serum bilirubin level.The cure and improvement rates were better in non-older-age group than in older-age group(χ2=1.97,P0.05). ConclusionALSS can significantly improve the clinical symptoms and biochemical index of patients with hepatitis E,raise the cure rate and reduce the incidence of serious hepatitis,which is especially important for hepatitis E in the elderly.