Relationship between ATP-binding cassette transporter A1 gene R219K polymorphism and serum lipid levels

Objective: To investigate the relationship between ATP-binding cassette transporter A1(ABCA1) gene R219K polymorphism and serum lipid levels,and the risk factors for coronary heart disease(CHD).Methods: ABCA1 gene R219K site G → A(Arg219Lys) of 227 cases of CHD and 162 cases of non-CHD were detected by polymerase chain-reaction restriction fragment length polymorphism(PCR-RFLP) technique so as to analyze the genotype frequencies,allele frequency distribution features and their correlations with lipid levels.Results: Compared with control group,the RR genotype frequency in the CHD group(42.3%) was significantly higher than that in control group(31.5%),which was of statistical difference(P0.05);while the KK-frequency(10.6%) was significantly lower than that of the control group(20.7%),which was statistically different(P0.05).The triglyceride(TG) levels(1.43±0.597)mmol/L of the KK genotype carrier in CHD group was lower than the RR genotype carrier(1.87±1.34)mmol/L(P0.05);High-density lipoprotein(HDL-C) levels carried by KK genotype(1.34±0.35)mmol/L was higher than that of the RR genotype(1.09±0.18)mmol/L,which was of statistical difference(P0.05).Conclusion: The ABCA1 gene R219K polymorphism is related to serum lipid levels,which is one of the predisposing factors causing the onset of coronary heart disease.