Clinical effect of early continued enteral nutrition support on severe stroke

Objective To observe the efficacy of early continued enteral nutrition support in severe stroke patients and its effect on immune function and prognosis. Methods A total of 86 cases of severe stroke were randomly divided into control group and observation group with 43 cases in each gorup. On the base of conventional treatment,the control group was fed concentrated,and observation group was given continued nutritional support,the course of treatment was 21 days. The nutrition indicators( ALB,Hb,TG),immune parameters( IgA,IgG,IgM),neurological deficits( NIHSS score) were determined and compared in the two groups,and infection rates and mortality were also compared. Results On day 1,the nutrition indicators,immune parameters and NIHSS scores of both groups were not statistically different. To 10 days,ALB, Hb,TG,IgA,IgG and IgM in both groups was significantly decreased than the first day( P 0. 05). To 21 days,the level of ALB,Hb,TG in the control group was( 35. 28 ± 4. 65) g / L,( 115. 16 ± 11. 92) g / L,( 0. 91 ± 0. 24) mmol / L,respectively,which all continued to show a downward trend,but the level of ALB,Hb and TG in the control group was( 38. 16 ± 5. 13) g / L,( 127. 31 ± 11. 85) g / L,( 1. 46 ± 0. 35) mmol / L,respectively,which were all higher than that of control group( P 0. 01) and was no significantly different compared to the first day( P 0. 05). To 21 days,the level of IgA,IgG and IgM in the control group was( 2. 27 ± 0. 39) g / L,( 9. 01 ± 1. 93) g / L,( 1. 39 ± 0. 31) g / L,respectively,but the level of IgA,IgG and IgM in the control group was( 2. 83 ± 0. 53) g / L,( 11. 28 ± 2. 05) g / L,( 1. 78 ± 0. 41) g / L,respectively, which were all higher than that of control group( P 0. 01) and was no significantly different compared to the first day( P 0. 05). The total infection rate of observation group was 23. 3%,which was significantly lower than that in the control group( 55. 8%),P 0. 01. To 21 days,the neurological deficit scores in the observation group were significantly lower than that in the control group( P 0. 01),within 3 months,the mortality of the control group was 11. 6%,also higher than that( 4. 7%) in the observation group,but there was no significant difference( P 0. 05). Conclusion Early continued enteral nutrition support can promote the recovery of neurological function in patients with severe stroke and improve the prognosis of the disease,and reduce the mortality at a certain extent,which may be related to improve nutritional status, and promote the recovery of immune function.