The comprehensive assessment of ~(131)I and ATD therapy for the patients with hyperthyroidism

Objective To comprehensively mark the treatment of hyperthyroidism with 131 I and antithyroid drugs(ATD) and to quantitatively assess the advantages and the disadvantages of them. Methods In two therapeutic methods of hyperthyroidism those being cured were marked 0,those getting better were marked 1,those remaining unchanged were marked 2. After treatment the patients demonstrated ophthalmopathy or more severe ophthalmopathy,hyperthyroid heart disease, liver function damage and leukopenia were marked 2,those showed temporary hypothyroidism and permanent hypothyroidism were marked 1,2,respectively.Those who had a relapse of the disease after being cured were marked 2.Both individual kinds of marks and total marks were compared. Results The total mark of group treated with 131 I was 319,and the average mark was 1.39;the total mark of group treated with ATD was 569,and the average mark was 2.20,the difference between the two groups was significant ( P 0.001).The incidences of ophthalmopathy of the two groups were not significantly different,but in improving ophthalmopathy the ATD excelled 131 I( P 0.05).The patients treated with 131 I contracted hypothyroidism more often than those treated with ATD( P =0.001).The patients cured with 131 I their hyperthyroidism relapse obviously less occurred than in those cured with ATD.In the patients treated with 131 I the incidences of hyperthyroid heart disease, liver function damage, leukopenia and so on were less than in those treated with ATD( P 0.001). Conclusions 131 I therapy excels the ATD in treatment of the patients with hyperthyroidism. Although there is certain incidence of hypothyroidism, ophthalmopathy and so on after 131 I treatment, its total curative effect is better than that of ATD.