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Role of the Rho/Rho-kinase pathway in the mechanism of hypoxic pulmonary vasoconstriction

Xiaodan Song

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Abstract

Objective To observe the signaling pathway of 15-hydroxyeicosatetraenoicacid(15-HETE) induced pulmonary artery constriction of rats,and clarify the possible mechanism of 15-HETE induced hypoxic pulmonary vasoconstriction.Methods Pulmonary arterial rings were used to assess the role of 15-HETE in pulmonary artery tension from hypoxic and normoxic rats,furthermore,the inhibitor of Rho-kinase signaling pathway was employed to determine the role of Rho/Rho-kinase signaling pathway in 15-HETE induced pulmonary vasoconstriction.Results 15-HETE constricted the pulmonary artery rings of both hypoxic and nomorxic rats;and Y-27632 reduced 15-HETE vasoconstriction effect significantly(P0.05).Conclusion 15-HETE constricts the pulmonary arteries of rats in chronic hypoxia via Rho/Rho-kinase signaling pathway.

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What this paper is about

Objective To observe the signaling pathway of 15-hydroxyeicosatetraenoicacid(15-HETE) induced pulmonary artery constriction of rats,and clarify the possible mechanism of 15-HETE induced hypoxic pulmonary vasoconstriction.Methods Pulmonary arterial rings were used to assess the role of 15-HETE in pulmonary artery tension from hypoxic and normoxic rats,furthermore,the inhibitor of Rho-kinase signaling pathway was employed to determine the role of Rho/Rho-kinase signaling pathway in 15-HETE induced pulmonary vasoconstriction.Results 15-HETE constricted the pulmonary artery rings of both hypoxic and nomorxic rats;and Y-27632 reduced 15-HETE vasoconstriction effect significantly(P0.05).Conclusion 15-HETE constricts the pulmonary arteries of rats in chronic hypoxia via Rho/Rho-kinase signaling pathway.

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Available abstract

Objective To observe the signaling pathway of 15-hydroxyeicosatetraenoicacid(15-HETE) induced pulmonary artery constriction of rats,and clarify the possible mechanism of 15-HETE induced hypoxic pulmonary vasoconstriction.Methods Pulmonary arterial rings were used to assess the role of 15-HETE in pulmonary artery tension from hypoxic and normoxic rats,furthermore,the inhibitor of Rho-kinase signaling pathway was employed to determine the role of Rho/Rho-kinase signaling pathway in 15-HETE induced pulmonary vasoconstriction.Results 15-HETE constricted the pulmonary artery rings of both hypoxic and nomorxic rats;and Y-27632 reduced 15-HETE vasoconstriction effect significantly(P0.05).Conclusion 15-HETE constricts the pulmonary arteries of rats in chronic hypoxia via Rho/Rho-kinase signaling pathway.

Key concepts: Hypoxic pulmonary vasoconstriction, Vasoconstriction, Rho-associated protein kinase, Hypoxia (environmental), Pulmonary artery, Constriction, Internal medicine, Rho kinase inhibitor

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Role of the Rho/Rho-kinase pathway in the mechanism of hypoxic pulmonary vasoconstriction — Research Paper | ScholarLens