Effects of telmisartan on the expression of myocardial β-myosin heavy chain in rats with renovascular hypertension

Objective To observe the effects of telmisartan on the expression of myocardial β-myosin heavy chain(β-MHC) mRNA in rats with two-kidney one clip(2K1C) ways.Methods Thirty male Sprague-Dawly(SD) rats were randomly divided into sham-operation group(sham group,n=10),model group(M group,n=10) and telmisartan group(T group,n=10).2K1C hypertensive model was established in SD rats by chronic partial occlusion of left renal artery.Eight weeks after the operation,the blood pressure was tested by arterial catheterization.The myocardial structure and function were obtained by ultrasonography,and the change of myocardial histopathology were observed by HE staining methods.RT-PCR was used to detect the expression of β-MHC mRNA in myocardial tissues.Results Eight weeks later,the blood pressure and the thickness of left ventricle in model group were significantly higher than those in sham group.The pathologic finding indicated the increasing diameter and irregular arrangement of myocytes.The blood pressure in T group were significantly lower than those in model group(P0.01,respectively).There are no markedly myocardial hypertrophy,and the β-MHC mRNA expression of myocardial tissue lower than that in model group(P0.05).Conclusion Telmisartan could decrease the expression of β-MHC,which may be one of mechanisms for the regression of myocardial hypertrophy.