2001•Dianzi xianwei xuebaoRequires access
Systemic amyloidosis——A histologic and ultrastructural observation of cutaneous changes
Tang Xiu
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Abstract
The histologic and ultrastructural changes of cutaneous lesion on systemic amyloidosis were observed. Histologically, the whole dermis and subepidermal of the skin were replaced by a large quantity of amorphous masses, a faintly eosinophilic substances. They were positive for Congo red, Alcian blue, and periodic acid Schiff (PAS) stains. Immunofluoscence examinations were negative for κ and λ.Ultrastructural observation demontrated characteristic amyloid fibrils. Morphologic observation is important in determining diagnosis of amyloidosis.