Clinical observation of conventional ventilation combined with sildenafil in treatment of persistent pulmonary hypertension of newborn

Objective To evaluate the effect and safety of conventional ventilation combined with sildenafil in the treatment of persistent pulmonary hypertension of newborn.Methods Forty-eight newborns with persistent pulmonary hypertension were randomly divided into sildenafil group(n=25)and control group(n=23).Control group received routine therapy including conventional ventilation,and sildenafil group received sildenafil(0.5to 2.0mg/kg)by nasal feeding,once per 6hours besides the therapy in control group.Results The pulmonary artery pressure,ratio of pulmonary artery pressure to systolic blood pressure decreased gradually in sildenafil group after treatment compared with before treatment(P0.05).There were significant differences in pa(O2)and oxygenation indexes in both two groups after treatment compared with before treatment(P0.05).There were significant differences in ventilation time,exposure time to oxygen and duration of hospitalization between two groups(P0.05),and no significant difference in fatality rate and incidence rates of pneumothorax and intracranial hemorrhages between two groups(P 0.05).Conclusions Conventional ventilation combined with sildenafil can effectively improve the result without increasing complications in persistent pulmonary hypertension of newborns.