ScholarLens Back to search
2006•Chinese Journal of Clinical NeurosciencesRequires access

Huntingtin and Huntington’s Disease

Gu Zhen

Open publisher page 1 citations

Abstract

Many of human diseases,including several neurodegenerative disorders are thought to be caused by misfolding and aggregation of a disease-causing protein. Huntington’s disease (HD) occurs due to an expansion of polyglutamine tract in the protein named huntingtin. Mutant huntingtin forms inclusions in the nucleus and aggregates in the cytoplasm in neurons. We reviewed the mechanisms of protein misfolding in Huntington’s disease and recent progress in developing therapies for HD aimed at preventing or correcting misfolding and aggregation of mutant huntingtin.

About this research paper

What this paper is about

Many of human diseases,including several neurodegenerative disorders are thought to be caused by misfolding and aggregation of a disease-causing protein. Huntington’s disease (HD) occurs due to an expansion of polyglutamine tract in the protein named huntingtin. Mutant huntingtin forms inclusions in the nucleus and aggregates in the cytoplasm in neurons. We reviewed the mechanisms of protein misfolding in Huntington’s disease and recent progress in developing therapies for HD aimed at preventing or correcting misfolding and aggregation of mutant huntingtin.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Many of human diseases,including several neurodegenerative disorders are thought to be caused by misfolding and aggregation of a disease-causing protein. Huntington’s disease (HD) occurs due to an expansion of polyglutamine tract in the protein named huntingtin. Mutant huntingtin forms inclusions in the nucleus and aggregates in the cytoplasm in neurons. We reviewed the mechanisms of protein misfolding in Huntington’s disease and recent progress in developing therapies for HD aimed at preventing or correcting misfolding and aggregation of mutant huntingtin.

Key concepts: Huntingtin, Polyglutamine tract, Huntington's disease, Huntingtin Protein, Disease, Protein aggregation, Mutant, Neurodegeneration

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Huntingtin and Huntington’s Disease — Research Paper | ScholarLens