1998•PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSRequires access

New Progress in Nuclear Receptor and It Mediated Transactivation:Coactivator and Corepressor

Mu Xiao

Abstract

Nuclear receptor belong to a superfamily of protein.Members of this family are characterized by similar three major structure region including a highly conserved DNA binding domain.Nuclear receptor bind to specific DNA sequence and control specific gene transcription.Recent data show that,in addtion to contacting to basal transcription factors,nuclear receptor inhibit or enhance transcription by recruiting the array of coactivator or corepressor.Coactivators are necessary for the efficient transcription.CBP/P300, SRC1and SMRT are the main coactivators and corepressor found so far.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Corepressor, Coactivator, Nuclear receptor, Nuclear receptor coactivator 1, Transactivation, Nuclear receptor coactivator 3, Nuclear receptor coactivator 2, Nuclear receptor co-repressor 1