Clinical characteristics of young patients aged less than 35 years old with acute myocardial infarction

Objective: To analyze the clinical characteristics of young patients aged less than 35 years old with acute myocardial infarction(AMI) and provide evidence for early diagnosis and treatment of AMI.Methods: Data of 117 young patients 35 years old with AMI admitted in our hospital during recent 10 years were chosen and another 355 aged patients 65 years old with AMI admitted in the same period were chosen as control.Data of their disease history,clinical data,medication and coronary angiography were compared and analyzed.Results: Among the young patients with AMI,those who had coronary artery disease family history(30.0%),smoked cigarettes(66.7%) and was male(96.6%) were more than those of aged patients(P0.05 all).ST segment elevation(69.2%) and anterior wall AMI(43.6%) were more seen in young patients.Compared with aged patients,young patients possessed higher level of low density lipoprotein-cholesterol [LDL-C,(2.35±1.21) mmol/L vs.(2.93±1.48) mmol/L,P0.05],higher left ventricular ejection fraction [LVEF,(48.31±12.48) % vs.(59.82±10.86) %,P0.05] after AMI.Results of coronary angiography indicated that most of the young patients were of single-vessel coronary disease(66.7%),left anterior descending lesion(69.3%);incidence rate of coronary spasm was significantly higher in young patients than that of aged patients(6.8 % vs.0.56%,P0.05).In-hospital death(2.6% vs.8.7%),and major adverse cardiovascular events after one month(3.4% vs.11.2%) and 12 months(14.5% vs.24.8%) of young patients were significantly better than those of aged patients(P0.05 all).Conclusion: Main risk factors of young patients under 35 years old with acute myocardial infarction include smoking cigarettes,hyperlipidemia,and family history.Education of smoking cessation and life style improvement is very important in young population in order to perform early prevention and lower the incidence of acute myocardial infarction in young people.