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2014•Zhonghua zhongyiyao zazhiRequires access

P38 MAPK and pain sensitization

Zhang Xiu-lia

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Abstract

As a class of serine/threonine protein kinases in eukaryotic cells, Mitogen-activated protein kinases(MAPKs) mainly included extracellular signal-regulated kinas(ERKs) family, the c-Jun NH2-terminal kinases(JNKs) family and P38 MAPKs family. It played an important role in stimulating the signal transduction from extracellular to cell and cell nucleus and the process of biological reaction. P38 MAPK signal transduction pathway was one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain, which was closely related to pain sensitization. A further research on the pain sensitization mechanism of P38 MAPK will provide a new therapeutic target in the treatment of pain sensitization diseases.

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What this paper is about

As a class of serine/threonine protein kinases in eukaryotic cells, Mitogen-activated protein kinases(MAPKs) mainly included extracellular signal-regulated kinas(ERKs) family, the c-Jun NH2-terminal kinases(JNKs) family and P38 MAPKs family. It played an important role in stimulating the signal transduction from extracellular to cell and cell nucleus and the process of biological reaction. P38 MAPK signal transduction pathway was one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain, which was closely related to pain sensitization. A further research on the pain sensitization mechanism of P38 MAPK will provide a new therapeutic target in the treatment of pain sensitization diseases.

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Available abstract

As a class of serine/threonine protein kinases in eukaryotic cells, Mitogen-activated protein kinases(MAPKs) mainly included extracellular signal-regulated kinas(ERKs) family, the c-Jun NH2-terminal kinases(JNKs) family and P38 MAPKs family. It played an important role in stimulating the signal transduction from extracellular to cell and cell nucleus and the process of biological reaction. P38 MAPK signal transduction pathway was one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain, which was closely related to pain sensitization. A further research on the pain sensitization mechanism of P38 MAPK will provide a new therapeutic target in the treatment of pain sensitization diseases.

Key concepts: Sensitization, p38 mitogen-activated protein kinases, MAPK/ERK pathway, Signal transduction, Kinase, Mitogen-activated protein kinase, Cell biology, Extracellular

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