The behavior effect of bFGF on dementia rats and the likelihood mechanism

Objective To study the effects of basic fibroblast growth factor (bFGF)on the learning and memory abilities of dementia rats and to reveal the likelihood mechanism. Methods We developed the dementia model through leisioning NBM by kainic acid. Dementia model rats received bFGF(dementia treatmemt group) or saline(dementia control group) by infusion into the cerebroventricular space at 30min,1d,3d and 7d after the operation. The learning and memory abilities were measured by Y-maze test at 30d after operation;Following by AchE cytochemistry and Nissl staining,then calculation the density of the AchE fiber of hippocampus and forebrain. Results Comparison to normal control group,learning and memory abilities of dementia group were declined and the density of AchE fiber was decreased significantly(P 0.01). In comparison with dementia control group,learning and memory abilities of dementia treatmemt group were improved and the density of AchE fiber was increased significantly(P 0.01). But all of the parametres in the treatmemt group did not reach the levels of normal group’(P 0.01). Conclusion It is showed that:(1) bFGF can improve the learning and memory abilities of the dementia rats. (2)The increasing of AchE fiber density and neuron density is the possible mechanism of the behavior effect of bFGF on dementia rats.