Correlation between ERCC1,ERCC2 expression and clinicopathological characters and prognosis in esophageal cancer

Objective Investigated the expression of ERCC1,ERCC2 in human esophageal cancer by immunohistochemical staining,analyzed the correlation with the clinicopathological features,and the impact on prognosis in order to evaluate the feasibility as prognosis marker of esophageal cancer.Methods To select 97 esophageal cancer patients gained complete follow-up data and 50 health esophageal and gastric cardiac tissue as control.To detect the expression of ERCC1,ERCC2 in esophageal cancer and normal tissue by S-P immunohistochemistry,and analyze the correlation of ERCC1,ERCC2 with clinicopathologic features and prognosis of esophageal cancer.Results The positive expression of ERCC1 and ERCC2 in esophageal cancer were 38.1% and 24.7%,respectively.ERCC1 expression in cancer was higher than that in normal tissue,but there wasn't significant statistical difference between them(P0.05),and ERCC2 expression in cancer was significantly higher than that in normal tissue(P0.05).Both ERCC1 and ERCC2 expression were significantly higher in well-differentiated cancer than those in moderately differentiated cancer and poor differentiation cancer(P0.05).Neither ERCC1 nor ERCC2 expression was correlated with sex,age,tumor location,length,depth,pathology type,lymph node metastasis or clinical stage.5-year survival rate of ERCC1-positive patients was 51.35%,which was higher than ERCC1-negative patients(26.67%).There was significant statistical difference between each other(P0.05).5-year survival rate of ERCC2-positive patients was 50.00%,which was higher than ERCC2-negative patients(31.51%).There was not significant statistical difference between each other,but it was seemed that ERCC2-positive patients had a better survival than ERCC2-negative patients(P=0.070).Conclusion ERCC1,ERCC2 were examined expression on different degree either in esophageal cancer or in normal tissue.There were positive correlation between the both ERCC1 and ERCC2 expression and differentiation degree of esophageal and gastric cardiac cancer.As the differentiation degree grew better,the positive rate became higher.ERCC1 and/or ERCC2-positive expression patients had better prognosis than co-negative expression patients.