Effects of different dose of sufentanil on hemodynamics of patients with tracheal intubation

Objective To compare the effects of different dose of sufentanil on hemodynamics and bispectral index to tracheal intubation and to investigate proper dose of sufentanil which can effectively inhibit the stress reaction of tracheal intubation.Methods Sixty ASAⅠor Ⅱ patients undergoing selective operation under general anesthesia were randomly divided into three groups with 20 cases for each group.The dose of sufentanil were 0.2 μg/kg(group Ⅰ),0.3 μg/kg(group Ⅱ)and 0.4 μg/kg(group Ⅲ),respectively.Propofol 2 mg/kg and vecuronium 0.1 mg/kg were injected 3 minites after sufentanil and tracheal intubation was performed then after.SBP,DBP,HR,BIS were recorded immediately before induction of anesthesia(T0),after intravenous sufentanil injection(T1),after intravenous propofol injection(T2),immediately after intubation(T3)and at 3 min after intubation(T4).Results Compared to that before anesthesia,there were no significant differences in SBP,DBP,BIS at T1,but they were all decreased at T2 in the three groups(P0.05 or P0.01),SBP,DBP were significantly higher in group Ⅰat T3(P0.05);SBP,DBP,BIS were higher in group Ⅰ than that in group Ⅱ at T3;While HR was not changed remarkably in the three groups during anesthesia induction.Conclusion Sufentanil 0.3 μg/kg combined with propofol 2 mg/kg for induction of anaesthesia can effectively depress the cardiovascular response to intubation,and causes less hemodynamic changes,which may be a rational dose clinically.