Effects and mechanisms of danshenyin on accelerate gastric ulcer healing

AIM: To investigate the effects and mechanisms of danshenyin on acetic acid-induced gastric ulcer. METHODS:When SD rats with acetic acid-induced gastric ulcer were treated with danshenyin for 14 days, the ulcer index,the level of nitric oxide (NO) in serum, Prostaglandin E_2(PGE_2) in plasma and the content of gastric wall binding mucus was measured, the apoptosis index and the protein expressions of Bcl-2, EGFR at the ulcer margin mucosa were detected. RESULTS:Compared with model group, danshenyin significantly attenuated acetic acid-induced gastric ulcer healing and produced a significant rise in the level of NO in serum, PGE_2 in plasma and the content of gastric wall binding mucus. Danshenyin also decreased the number of epithelial apoptosis (P(0.05), P(0.01) respectively,), meanwhile, the density and area of Bcl-2 and EGFR expression were markedly increased after the treatment with danshenyin, and danshenyin 7, (3.5) (g·kg~(-1)) groups had more significance on it among three groups(P(0.01)).CONCLUSION: Danshenyin plays a role in accelerating ulcer healing by gastric mucosal defensive factors and inhibiting apoptosis pathways, which may be one of its anti-ulcer action mechanisms.