2002•Zhongguo yaofangRequires access

Experimental Study on the in Vivo Antibacterial Effects of Norfloxacin Injection in Animals

Liu Xianjue

Abstract

OBJECTIVE:To study the in vivo antibacterial effects of Norfloxacin injection in animals.METHODS:After infecting the animals by injection of Escherichia coli and Staphylococcus aureus suspension into the mice's abdominal cavity and rabbit's body,the animals were divided into therapy,prophylaxis and control groups to observe the effect of Norfloxacin.RESU-LTS:All mice of control group died within 24 hours after the injection of bacteria while those of the therapy and prophylaxis groups survived.The results of experiment on rabbits were similar to those on mice.CONCLUSION:The results show that Norfloxacin injection has obvious therapeutic and prophylactic effects on infections induced by E.coli and Staphylococcus aureus.

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Key concepts: Norfloxacin, Staphylococcus aureus, In vivo, Escherichia coli, Pharmacology, Intraperitoneal injection, Peritoneal cavity, Microbiology