Determination of 14 organic solvent residues in cosmetics by headspace gas chromatography-mass spectrometry

Objective To develop a method for simultaneous determination of 14 organic solvent residues in cosmetics by automated headspace gas chromatography- mass spectrometry. Methods The experimental conditions of headspace( such as temperature,time and sample volume),GC and sample treatment were optimized to establish a method for analysis of organic solvent residues in cosmetics. Cosmetic samples were extracted by headspace at 90 ℃ for 30 min,then separated by HP- INNOWAX capillary column,and determined by GC- MS. The retention time of the peaks was used for qualitative analysis,while external standard method was used for quantitative analysis. Results The method had good linearity over the range of 0. 05 mg / L ~ 50 mg / L for 12 orgainc solvent residues,while that of acrylonitrile and acetonitrile was between 0. 5 mg / L ~ 50 mg / L. The detection limits of the 14 organic solvents ranged from 1 mg / kg to 3 mg / kg with recoveries of 73. 6 % ~ 98. 5 % and relative standard deviation( RSD) of 1. 7% ~ 6. 7%( n = 6). Conclusion The method is simple,rapid,sensitive and stable,it is suitable for simultaneous monitoring of 14 organic solvent residues in cosmetics.