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2006•Chinese Journal of Hospital PharmacyRequires access

The relative bioavailability of rifampicin of compound isoniazid capsules in dogs

Zhou Gang

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Abstract

OBJECTIVE To study the relative bioavailability of rifampicin of compound isoniazid capsules in dogs.METHODS Six dogs were enrolled in a randomized crossover study with a single oral dose of the two formulations respectively.The rifampicin in plasma was measured by HPLC.RESULTS The pharmacokinetic parameters of test and reference preparation for rifampicin were: t_max(3.8±1.7) and(3.3±0.8) h,C_max(38.8±10.9) and(37.8±9.1) mg·L~-1,AUC_0→∞(583.2±188.5) and(583.7±200.9) mg·h·L~-1,AUC_0→∞(605.1±197.2) and (596.4±202.1) mg·h·L~-1, t_1/2(9.5±1.5) and(9.1±1.4)h,F(102.8±17.3) %. CONCLUSION The results of the statistical analysis show that the two rifampicin preparations are bioequivalent.

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OBJECTIVE To study the relative bioavailability of rifampicin of compound isoniazid capsules in dogs.METHODS Six dogs were enrolled in a randomized crossover study with a single oral dose of the two formulations respectively.The rifampicin in plasma was measured by HPLC.RESULTS The pharmacokinetic parameters of test and reference preparation for rifampicin were: t_max(3.8±1.7) and(3.3±0.8) h,C_max(38.8±10.9) and(37.8±9.1) mg·L~-1,AUC_0→∞(583.2±188.5) and(583.7±200.9) mg·h·L~-1,AUC_0→∞(605.1±197.2) and (596.4±202.1) mg·h·L~-1, t_1/2(9.5±1.5) and(9.1±1.4)h,F(102.8±17.3) %. CONCLUSION The results of the statistical analysis show that the two rifampicin preparations are bioequivalent.

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Available abstract

OBJECTIVE To study the relative bioavailability of rifampicin of compound isoniazid capsules in dogs.METHODS Six dogs were enrolled in a randomized crossover study with a single oral dose of the two formulations respectively.The rifampicin in plasma was measured by HPLC.RESULTS The pharmacokinetic parameters of test and reference preparation for rifampicin were: t_max(3.8±1.7) and(3.3±0.8) h,C_max(38.8±10.9) and(37.8±9.1) mg·L~-1,AUC_0→∞(583.2±188.5) and(583.7±200.9) mg·h·L~-1,AUC_0→∞(605.1±197.2) and (596.4±202.1) mg·h·L~-1, t_1/2(9.5±1.5) and(9.1±1.4)h,F(102.8±17.3) %. CONCLUSION The results of the statistical analysis show that the two rifampicin preparations are bioequivalent.

Key concepts: Bioequivalence, Rifampicin, Bioavailability, Isoniazid, Pharmacokinetics, Pharmacology, Crossover study, Chemistry

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