Effects of dexmedetomidine on blood pressure in old hypertesion patients undergoing spinal-epidural combined anesthesia

Objective To investigate the effects of dexmedetomidine on peri-operation periods blood pressure of old hypertension patients.Methods 75 patients who were 65-70 years old,ASA Ⅱ or Ⅲ undergoing prostate vaporized excision were randomly divided into three groups:control group,midazolam group and dexmedetomidine group.Blood pressure,heart rate and SPO2 was recorded at pre-admistration,5 min after ad ministration,30 min and 2h after anaethsia.Results Contractive pressure and heart rates were increased in control group.Contractive pressure and heart rates were no more or less changed in midazolam group,SPO2 was decreased to(89.4±3.2)% at 5 min after ad ministration,raising submaxilla could relieve respiratory inhibition resluted by midazolam.Contractive pressure in dexmedetomidine group was decreased gently,the incidence rate of hypotension was not increased.Conclusion Circulation is stabilized in anesthetic phase by small dose dexmedetomidine administrated by dropping nasal with sedation and center depressurization,which can be helpful for safety of peri-operation of old hyprtension patients.