Effect of angiotensin(1-7) on myocardial remodeling in pressure loaded hypertensive rats

Objective To investigate the effect of angiotensin(1-7) on myocardial remodeling which induced by pressure overload in rats.Methods Thirty SD rat were randomly divided into 3 groups.Left ventricular hypertrophy was induced by abdominal aortic constriction(AAC) and received angiotensin(1-7)(25μg ? kg~(-1) ? h~(-1) )(n = 10).Sham operated rats (n = 10) and untreated AAC rats(n= 10) served as controls.Systolic blood pressure(SBP) and LVMI were determined, cardiomyocytes diameter were measured by HE stain;plasma angiotensinⅡand myocardial angiotensinⅡlevels was detected by radioimmunoassay.Results Compared with sham operation group,SBP,LVMI,mean diameter of cardiomyocytes and myocardial angiotensinⅡconcentration in AAC rats were significantly increased(P 0.05,P 0.01).SBP and myocardial angiotensinⅡconcentration had no significant differences between AAC rats and Ang(1-7) rats(P 0.05).while LVMI, mean diameter of cardiomyocytes in Ang(1-7) rats were significantly decreased(all P 0.05).Conclusion Ang(1-7) could prevent the development of myocardial hypertrophy in pressure overloaded rats and reverse myocardial remodeling.