1999•Di-Si Junyi Daxue xuebaoRequires access
The expression and significance of Pgp in wilms' tumor and medulloblastoma in children
Meng Yu
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Abstract
AIM: To study the expression
and significance of Pgp in wilms' tumor and medulloblastoma. METHODS: Pgp was
detected in 46 cases with wilms' tumor and 25 cases with medulloblastomas in children
by SABC immuohistochemical methods. RESULTS: 7(15.2%) cases with wilms' tumors were
Pgp positive while 11( 44.0%) cases with medulloblastomas were Pgp positive. Statistical
analysis revealed that expression of Pgp was significantly correlated with chemotherapy and
NWTS Ⅱ classification of nephroblastoma( P 0.05), but there was no correlationship
between expression of Pgp and NWTS Ⅲ clinical pathological stages of
nephroblastomsas ( P 0.05). There was not correlationship between the expression of Pgp
and clinical pathological classification of medulloblastomas ( P 0.05). CONCLUSION:
Expression of Pgp,which could be induced and promoted by chemotherapy, may be an
important parameter in the evaluation of malignance and prognosis of wilms' tumor. There was
no correlationship between the expression of Pgp and clinical pathological classification of
medulloblastomas.