Study on clinical efficacy of ulinastatin in patients with acute respiratory distress syndrome

Objective To study the effect of ulinastatin on MDA,SOD in serum of patients with ARDS,explore the lung protection of ulinastatin and the possible mechanism.Methods Forty patients with ARDS were randomly divided into two groups:ulinastatin group(n=20)were administered with ulinastatin in addition to the conventional therapy,and non-ulinastatin group(n=20)underwent the conventional therapy.During the study,serun cytokines including MDA,SOD were measured,and the breathing frequency,PO2,PCO2,oxygention index were monitorred.Results The MDA in serum of ulinastatin group was significantly decreased after therapy compared with non-ulinastatin group,The SOD in serum of ulinastatin group was significantly increased after therapy compared with non-ulinastatin group.And ulinastatin can improve the respirations index of patients.Conclusions ulinastatin can decrease the inflammatory cell and the oxyradical,so ulinastatin plays a role in lung protecting to patients with ARDS.