Detection of the intestinal permeability of infected fracture patient and its clinical significance

Objective To assess the intestinal barrier function of the infected fracture patient by studying the intestinal permeability. Method The 10 infected fracture patients, the 10 fracture patients with no infection and 10 healthy volunteers were enrolled in this study. After ingestion of polyethylene glycolin 600 (PEG600), a 6 hous-urine collection was used to analyze the amount of urinal PEG600 by spectrophotometric assay. Result The measurement of PEG600 indicated that urinal PEG600 of infected fracture patients (95.063 ±9.961 μg) were significantly higher than that of the health volunteers and non-infected fracture patients (84.970 ±9.115, 81.813± 11.102 μg, P 0.05). Conclusion The intestinal permeability of the infected fracture patient is increased. The infected fracture patient may have intestinal barrier dysfunction.